IL-2 receptor gene expression and IL-2 production by human preterm newborns' cells
نویسندگان
چکیده
منابع مشابه
Modeling IL-2 gene expression in human regulatory T cells.
Interleukin-2 (IL-2) is one of the first cytokines to be expressed by T helper cells (Th cells) after antigen-specific stimulation. In contrast, regulatory T cells (T(reg) cells) do not express IL-2, although they are activated via the same pathways. In regulatory T cells the additional transcription factor FoxP3 is expressed. Using intracellular measurement of the transcription factors NFAT an...
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BACKGROUND IL-2 production has been measured in several disease including type I diabetes mellitus, systemic lupus erythematosus, acquired immunodeficiency syndrome and active pulmonary sarcoidosis and its pathogenetic role was suggested. In IgA nephropathy, altered T cell subsets were reported to be associated with increased synthesis of IgA. The altered IL-2 production and the expression of I...
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Human NK cell activity can be augmented in vitro by stimulation with IL-2 or IL-12, both of which also induce the production of IFN-gamma, TNF-alpha, and granulocyte-macrophage CSF by NK cells. For the first time, we demonstrate that freshly purified NK cells stimulated with IL-2 proliferated and produced IL-10 in a dose-dependent manner. IL-10 mRNA expression, as detected by semiquantitative r...
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Background Group 2 innate lymphoid cells (ILC2) are characterized by their expression of cytokines including IL-5 and IL-13 in response to IL-33. ILC2 are critical in mediating influenza virus-induced airway hypersensitivity and are associated with allergic inflammation. However, the factors regulating human ILC2 (hILC2) cytokine responses are not fully defined. In this study, we tested the hyp...
متن کاملThe roles of IL-2, IL-7, and IL15 Ligands in B Cells development
Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as -common family have an essential cytokines may support either synergistically or in an additive m...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 1993
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.1993.tb08204.x